Nitrogen Mustard as a Therapeutic Agent for Hodgkin's Disease, Lymphosarcoma and Leukemia

Article1 October 1947NITROGEN MUSTARD AS A THERAPEUTIC AGENT FOR HODGKIN'S DISEASE, LYMPHOSARCOMA AND LEUKEMIAMAXWELL M. WINTROBE, F.A.C.P., CHARLES M. HUGULEY JR., MARGARET T. MCLENNAN, LUCIO PENNA DE CARVALHO LIMAMAXWELL M. WINTROBE, F.A.C.P., CHARLES M. HUGULEY JR., MARGARET T. MCLENNAN, LUCIO PENNA DE CARVALHO LIMAAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-4-529 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe nitrogen mustards differ from the mustard war gas only in that nitrogen replaces sulfur. Study of the biological effects of the nitrogen mustards has revealed that they parallel and are almost identical with the biological effects of radiant energy.The most important properties of the beta chloroethyl amines (nitrogen mustards) are outlined in table 1. While these substances are stable andunreactive in dry form, in aqueous solution a rapid change takes place. The beta carbon forms a ring with the nitrogen to make a quaternary ammonium base, with the release of chloride ion. The quaternary ammonium ion is...Bibliography1. GILMANPHILIPS AFS: The biologic actions and therapeutic applications of the B-chloroethyl amines and sulphides, Science, 1946, ciii, 409. CrossrefGoogle Scholar2. GILMANGOODMANLINDSKOGDOUGHERTY ALGET: 1942-43. (See GILMAN, A. and PHILIPS, F. S.1) Google Scholar3. JACOBSONSPURRBARRONSMITHLUSHBAUGHDICK LOCLESTCGF: Nitrogen mustard therapy. Studies on the effect of methyl-bis (beta-chloroethyl) amine hydrochloride on neoplastic diseases and allied disorders of the hemopoietic system, Jr. Am. Med. Assoc., 1946, cxxxii, 263. CrossrefGoogle Scholar4. WINTROBEMCLENNANHUGULEY MMMTCM: Clinical experiences with nitrogen mustard therapy, Tumor Symposium, Am. Assoc. Adv. Sci., 1947. (To be published.) Google Scholar5. GOODMANWINTROBEDAMESHEKGOODMANGILMANMCLENNAN LSMMWMJAMT: Nitrogen mustard therapy. Use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders, Jr. Am. Med. Assoc., 1946, cxxxii, 126. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Salt Lake City, Utah*Read at the meeting of the American College of Physicians, Chicago, Illinois, May 1, 1947.This study was aided by a grant made by the American Cancer Society on the recommendation of the Committee on Growth of the National Research Council.From the Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah.†Fellow of the American Cancer Society.‡On leave from the University of Sao Paulo, Sao Paulo, Brazil. 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After intravenous administration of diethyl β‐radioiodoethyl amine hydrochloride and of radioactive sodium iodideChemotherapy of Neoplastic DiseasesRecent Advances in the Treatment of Leukemia in ChildrenHematologyChemotherapy of malignant diseaseOn the Use of Nitrogen Mustard as a Therapeutic AgentxThe nitrogen mustards in the treatment of leukemiaThe Therapeutic Indications for Nitrogen Mustards in LymphomaThe use of the nitrogen mustards in the palliative treatment of carcinoma.With particular reference to bronchogenic carcinomaNitrogen-mustard therapy for hodgkin's disease, lymphosarcoma, the leuke-mias, and other disordersThe histological effects of nitrogen mustards on human tumors and tissuesChemotherapy of Neoplastic DiseaseNitrogen mustard therapy 1 October 1947Volume 27, Issue 4Page: 529-540KeywordsChloridesHodgkin lymphomaLymphocytic leukemiaSalts ePublished: 1 December 2008 Issue Published: 1 October 1947 PDF downloadLoading ...