Key result
Young adults with a positive family history of CHD had significantly greater carotid intima-media thickness compared to those without a family history (0.600 vs 0.578 mm; P=0.003).
Why the study?
Does a family history of CHD increase subclinical atherosclerosis and arterial vulnerability to metabolic risk factors in young adults?
Population
2,265 white adults, 24 to 39 years of age, participating in the 21-year follow-up of the Cardiovascular Risk…
Comparison
Positive family history of coronary heart disease vs Negative family history of coronary heart disease
Design
Cohort
Follow-up
21 years
Authors
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Family history of CHD was associated with greater carotid IMT in young adults; leaves open whether it identifies a subgroup with heightened metabolic vulnerability.
Cohort (n=2,265)
Does a family history of CHD increase subclinical atherosclerosis and arterial vulnerability to metabolic risk factors in young adults?
Absolute Event Rate: 0.6% vs 0.578%
p-value: p=0.003
Young adults with a family history of CHD have increased subclinical atherosclerosis (carotid IMT), which is partly driven by a heightened vulnerability to metabolic risk factors.
Juonala et al. (2006) conducted a cohort in Healthy young adults (n=2,265). Positive family history of CHD vs. Negative family history of CHD was evaluated on Carotid artery intima-media thickness (IMT) (p=0.003). Young adults with a positive family history of CHD had significantly greater carotid intima-media thickness compared to those without a family history (0.600 vs 0.578 mm; P=0.003).
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