Female sex was associated with a significantly lower risk of angiographic restenosis compared to male sex after coronary stenting (28.9% vs 33.9%; adjusted OR 0.77, 95% CI 0.63-0.93).
Cohort (n=4,374)
Does female sex reduce the risk of angiographic and clinical restenosis in patients undergoing coronary stenting compared to male sex?
Women have a significantly lower risk of restenosis after coronary stenting compared to men, despite a higher prevalence of risk factors such as diabetes and small vessel size.
Odds Ratio: 0.77 (95% CI 0.63–0.93)
Absolute Event Rate: 28.9% vs 33.9%
p-value: p=0.01
AIMS: To examine the impact of sex on restenosis in a large cohort of consecutive patients undergoing coronary stenting and systematic angiographic and clinical follow-up. METHODS AND RESULTS: The study includes a cohort of 4374 consecutive patients (1025 women and 3349 men), undergoing coronary stenting for stable or unstable angina. Follow-up angiography at 6 months was performed in 80% of patients. Clinical events were assessed for a period of 1 year after the procedure. Main end-points of the study were angiographic and clinical restenosis at follow-up. Compared to men, women were older, presented more often with diabetes, smaller vessel size and shorter lesions. Clinical restenosis (need for reintervention) was found in 14.8% of women and 17.5% of men (P=0.048). The incidence of angiographic restenosis was significantly lower in women then in men (28.9% vs 33.9%, respectively, P=0.01). After adjustment for other covariates, women presented a 23% reduction of the risk of restenosis: odds ratio 0.77 (95% confidence interval 0.63 to 0.93). While a small vessel size was a risk factor for restenosis in both sexes, the influence of diabetes on restenosis was mostly confined to women. CONCLUSION: Compared with men, women present a lower risk of restenosis after coronary stenting despite a more preponderant presence of two major risk factors for restenosis, diabetes and small vessel size. There are sex-based differences in predictive factors of restenosis with diabetes having a particularly strong impact in women.
Julinda Mehilli (Fri,) conducted a cohort in stable or unstable angina undergoing coronary stenting (n=4,374). Female sex vs. Male sex was evaluated on angiographic restenosis (OR 0.77, 95% CI 0.63 to 0.93, p=0.01). Female sex was associated with a significantly lower risk of angiographic restenosis compared to male sex after coronary stenting (28.9% vs 33.9%; adjusted OR 0.77, 95% CI 0.63-0.93).