Key result
Percutaneous pulmonary valve implantation with the Melody valve provided similar 10-year estimated survival compared to surgical replacement (94% vs 92%, P=0.47).
Why the study?
Studies directly comparing the long-term outcome of PPVI using the Melody valve to SPVR were lacking.
Does percutaneous pulmonary valve implantation with the Melody valve provide similar survival and freedom from reintervention compared to surgical pulmonary valve replacement in patients with right ventricular outflow tract dysfunction?
Population
452 patients treated with PPVI with the Melody valve or SPVR at a single center
Comparison
PPVI with the Melody valve vs SPVR with different types of valves
Design
Single-center comparative cohort study
Follow-up
Median 5.4 years (3 months to 12.5 years)
Authors
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Comparable long-term survival and reintervention rates with Melody PPVI versus SPVR; extends single-center data but leaves open randomized confirmation.
Cohort (n=452)
No
Does percutaneous pulmonary valve implantation with the Melody valve provide similar survival and freedom from reintervention compared to surgical pulmonary valve replacement in patients with right ventricular outflow tract dysfunction?
Absolute Event Rate: 94% vs 92%
p-value: p=0.47
Percutaneous pulmonary valve implantation with the Melody valve provides similar long-term survival and freedom from reintervention compared to surgical pulmonary valve replacement, supporting its use as a less invasive alternative.
Georgiev et al. (2020) conducted a cohort in Right ventricular outflow tract dysfunction (n=452). Percutaneous pulmonary valve implantation (PPVI) with the Melody valve vs. Surgical pulmonary valve replacement (SPVR) was evaluated on Estimated survival after 10 years (p=0.47). Percutaneous pulmonary valve implantation with the Melody valve provided similar 10-year estimated survival compared to surgical replacement (94% vs 92%, P=0.47).
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