Key result
SEA0400 (1 microM) inhibited the NCX current by >80% without significantly affecting other membrane currents, demonstrating 10-fold higher potency and greater selectivity than KB-R7943.
Population
Isolated guinea-pig ventricular myocytes
Comparison
SEA0400 (1 microM) vs KB-R7943 (10 microM)
Design
Preclinical
Authors
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Offers potent NCX tool for myocyte studies; leaves open clinical translation in heart disease.
Absolute Event Rate: 80% vs 80%
SEA0400 is a potent and highly selective inhibitor of the Na(+)-Ca(2+) exchanger, providing a powerful tool for studying the role of NCX in the heart.
Tanaka et al. (2002) studied this question. SEA0400 vs. KB-R7943 (10 microM) was evaluated on NCX current inhibition. SEA0400 (1 microM) inhibited the NCX current by >80% without significantly affecting other membrane currents, demonstrating 10-fold higher potency and greater selectivity than KB-R7943.
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