Key result
MgATP stimulates cardiac Na(+)-Ca2+ exchange current likely via changes in charged membrane lipids, involving a transmembrane, oxidation-sensitive protein and aminophospholipid translocase.
Population
Giant excised inside-out membrane patches from guinea-pig and rabbit myocytes
Comparison
Application of MgATP, charged amphiphiles… vs Untreated or basal conditions
Design
Preclinical
Authors
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Positively charged detergents inhibit NCX current independently of surface potential; leaves open direct modulation in intact myocytes.
This preclinical study provides mechanistic insights into how MgATP stimulates cardiac Na(+)-Ca2+ exchange current, suggesting the involvement of aminophospholipid translocase and changes in membrane lipid charge.
Hilgemann et al. (1992) studied this question. MgATP and charged amphiphiles/phospholipids vs. Basal conditions was evaluated on Na(+)-Ca2+ exchange current stimulation. MgATP stimulates cardiac Na(+)-Ca2+ exchange current likely via changes in charged membrane lipids, involving a transmembrane, oxidation-sensitive protein and aminophospholipid translocase.
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