Severe mental illness was associated with a significantly lower likelihood of receiving equitable medication prescriptions for comorbid physical disorders compared to individuals without mental illness (OR 0.74).
Meta-Analysis (n=1,931,509)
Does the presence of mental illness reduce the likelihood of receiving equitable prescription of medications for physical disorders compared to individuals without mental illness?
Individuals with severe mental illness are significantly less likely to be prescribed common medications for physical disorders, particularly cardiovascular medications, highlighting a major disparity in medical care.
Odds Ratio: 0.74 (95% CI 0.63–0.86)
p-value: p=0.001
BACKGROUND: There is some concern that patients with mental illness may be in receipt of inferior medical care, including prescribed medication for medical conditions. AIMS: We aimed to quantify possible differences in the prescription of medication for medical conditions in those with v. without mental illness. METHOD: Systematic review and random effects meta-analysis with a minimum of three independent studies to warrant pooling by drug class. RESULTS: We found 61 comparative analyses (from 23 publications) relating to the prescription of 12 classes of medication for cardiovascular health, diabetes, cancer, arthritis, osteoporosis and HIV in a total sample of 1 931 509 people. In those with severe mental illness the adjusted odds ratio (OR) for an equitable prescription was 0.74 (95% CI 0.63-0.86), with lower than expected prescriptions for angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (ACE/ARBs), beta-blockers and statins. People with affective disorder had an odds ratio of 0.75 (95% CI 0.55-1.02) but this was not significant. Individuals with a history of other (miscellaneous) mental illness had an odds ratio of 0.95 (95% CI 0.92-0.98) of comparable medication with lower receipt of ACE/ARBs but not highly active antiretroviral therapy (HAART) medication. Results were significant in both adjusted and unadjusted analyses. CONCLUSIONS: Individuals with severe mental illness (including schizophrenia) appear to be prescribed significantly lower quantities of several common medications for medical disorders, largely for cardiovascular indications, although further work is required to clarify to what extent this is because of prescriber intent.
Mitchell et al. (Sat,) conducted a meta-analysis in Comorbid physical disorders in mental illness (n=1,931,509). Severe mental illness vs. No mental illness was evaluated on Equitable prescription of medication for medical conditions (OR 0.74, 95% CI 0.63-0.86, p=0.001). Severe mental illness was associated with a significantly lower likelihood of receiving equitable medication prescriptions for comorbid physical disorders compared to individuals without mental illness (OR 0.74).