Key result
Turnip crinkle virus evades nonsense-mediated decay via a 51-nucleotide unstructured RNA region downstream of the coat protein termination codon, a feature also enriched in human NMD-resistant transcripts.
Why the study?
RNA viruses often contain internally located stop codons that should make them prime targets for host nonsense-mediated decay, but how they evade this pathway is unclear.
The Turnip crinkle virus genome contains specific unstructured regions that confer resistance to host nonsense-mediated decay, a strategy that may be widespread among RNA viruses.
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Identifies conserved NMD-evasion motif across kingdoms; leaves open therapeutic targeting in human transcriptopathies.
May et al. (2018) studied RNA virus infection. Unstructured RNA regions downstream of termination codons vs. Structured RNA regions was evaluated on Nonsense-mediated decay (NMD) resistance. Turnip crinkle virus evades nonsense-mediated decay via a 51-nucleotide unstructured RNA region downstream of the coat protein termination codon, a feature also enriched in human NMD-resistant transcripts.
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