Key result
Plasma levels of IL-6, IL-8, IL-18, and procalcitonin were significantly elevated in patients with multiple organ dysfunctions following myocardial revascularization compared to those with SIRS alone.
Why the study?
Do plasma levels of proinflammatory cytokines and procalcitonin differ between patients with and without multiorgan dysfunction following cardiac surgery?
Observational (n=27)
Do plasma levels of proinflammatory cytokines and procalcitonin differ between patients with and without multiorgan dysfunction following cardiac surgery?
Elevated levels of IL-6, IL-8, IL-18, and procalcitonin are associated with the development of multiple organ dysfunction syndrome following cardiopulmonary bypass, with IL-18 identified as a novel marker.
May aid early MODS risk stratification after CPB; hypothesis-generating and requires prospective validation before clinical adoption.
Cardiopulmonary bypass is associated with an injury that may cause pathophysiological changes in the form of systemic inflammatory response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS). In the present study, we investigated the inflammatory response of patients with multiple organ dysfunctions following open-heart surgery. Plasma levels of cytokines (IL-1beta, IL-6, IL-8, IL-18) and procalcitonin (PCT) were measured on the first four postoperative days in 12 adult male patients with SIRS and two or more organ dysfunctions after myocardial revascularization (MODS group), and 15 patients without organ dysfunctions (SIRS group). All cytokines (except IL-1beta) and PCT were significantly elevated in MODS patients, with peak values at the first two postoperative days. The results of our study show a different expression of members of the IL-1 family following extracorporeal circulation. For the first time, we can document that IL-18 is involved in the inflammatory response and the initiation of the MODS following cardiopulmonary bypass. In addition to APACHE-II score, PCT, IL-8, and IL-18 may be used as parameters for the prognosis of patients with organ dysfunctions after cardiac surgery. Furthermore, it must be noted that the duration of the surgical procedure is one of the most important factors for the initiation of the inflammatory response.
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Sablotzki et al. (2002) conducted an observational in Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) following cardiac surgery (n=27). Multiple organ dysfunction syndrome (MODS) vs. Systemic inflammatory response syndrome (SIRS) without organ dysfunctions was evaluated on Plasma levels of cytokines (IL-1beta, IL-6, IL-8, IL-18) and procalcitonin (PCT). Plasma levels of IL-6, IL-8, IL-18, and procalcitonin were significantly elevated in patients with multiple organ dysfunctions following myocardial revascularization compared to those with SIRS alone.
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