Key result
Upregulation of the miR-15 family during the neonatal period regulates cardiomyocyte cell cycle withdrawal, with miR-195 expression almost 6-fold higher at day 10 versus day 1.
Population
Mice
Comparison
Overexpression of miR-195 or knockdown of the… vs Control/wild-type mice (implied)
Design
Preclinical
Authors
Loading...
May guide miR-15 targeting to promote neonatal cardiomyocyte mitosis; leaves open translation to adult human regeneration.
The miR-15 family, particularly miR-195, plays a crucial role in regulating postnatal cardiomyocyte cell cycle withdrawal and terminal differentiation.
Porrello et al. (2011) studied Cardiomyocyte cell cycle withdrawal. miR-195 overexpression and miR-15 family knockdown vs. Wild-type or baseline (P1) was evaluated on Cardiomyocyte cell cycle withdrawal, binucleation, and expression of cell cycle genes including Chek1. Upregulation of the miR-15 family during the neonatal period regulates cardiomyocyte cell cycle withdrawal, with miR-195 expression almost 6-fold higher at day 10 versus day 1.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: