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This research demonstrates how sphingolipid-containing vesicles reduce macrophage immune response to Porphyromonas gingivalis, suggesting potential therapeutic avenues.
Sphingolipids (SLs) are essential structural components of mammalian cell membranes. Our group recently determined that the oral anaerobe Porphyromonas gingivalis delivers its SLs to host cells and that the ability of P. gingivalis to synthesize SLs limits the elicited host inflammatory response during cellular infection.
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Rocha et al. (2020) studied this question.
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