Key result
Psychotropic drugs, particularly chlorpromazine and depot antipsychotics, were associated with prolonged QTc intervals in 6.7% of medicated patients with schizophrenia.
Why the study?
Do specific psychotropic drugs increase the frequency of QTc lengthening in patients with schizophrenia?
Observational (n=263)
Do specific psychotropic drugs increase the frequency of QTc lengthening in patients with schizophrenia?
Chlorpromazine and depot antipsychotic medications are significant predictors of prolonged QTc intervals in patients with schizophrenia, highlighting the need for ECG monitoring in this population.
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ECG monitoring warranted with chlorpromazine or certain depots in schizophrenia; leaves open prospective arrhythmia risk confirmation.
Chong et al. (2003) conducted an observational in Schizophrenia (n=263). Psychotropic drugs (chlorpromazine, flupenthixol decanoate, fluphenazine decanoate) vs. Healthy volunteers (for normal limits) was evaluated on Prolonged QTc interval. Psychotropic drugs, particularly chlorpromazine and depot antipsychotics, were associated with prolonged QTc intervals in 6.7% of medicated patients with schizophrenia.
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