Key result
Major depressive disorder was associated with significantly lower nodal local efficiency at the left middle occipital gyrus compared to healthy controls (0.56 vs. 0.81, pFDR < 0.05).
Why the study?
Dysfunctional brain networks have been found in patients with major depressive disorder, prompting an investigation into the intrinsic organization of brain networks using resting-state functional near-infrared spectroscopy.
Does resting-state fNIRS reveal dysfunctional brain network organization in patients with major depressive disorder compared to healthy controls?
Case-Control (n=64)
Does resting-state fNIRS reveal dysfunctional brain network organization in patients with major depressive disorder compared to healthy controls?
Absolute Event Rate: 0.56% vs 0.81%
p-value: pFDR < 0.05
Patients with major depressive disorder exhibit a more integrated brain network with lower nodal local efficiency at the occipital hub, which correlates with depressive symptoms.
May indicate occipital network inefficiency in MDD; hypothesis-generating and requires replication before clinical relevance.
Dysfunctional brain networks have been found in patients with major depressive disorder (MDD). In this study, to verify this in a more straightforward way, we investigated the intrinsic organization of brain networks in MDD by leveraging the resting-state functional near-infrared spectroscopy (rs-fNIRS). Thirty-four MDD patients (24 females, 38.41 ± 13.14 years old) and thirty healthy controls (22 females, 34.43 ± 5.03 years old) underwent a 10 min rest while their brain activity was recorded via fNIRS. The results showed that MDD patients and healthy controls exhibited similar resting-state functional connectivity. Moreover, the depression group showed lower small-world Lambda (1.12 ± 0.04 vs. 1.16 ± 0.10, p = 0.04) but higher global efficiency (0.51 ± 0.03 vs. 0.48 ± 0.05, p = 0.03) than the control group. Importantly, MDD patients, as opposed to healthy controls, showed a significantly lower nodal local efficiency at the left middle occipital gyrus (0.56 ± 0.36 vs. 0.81 ± 0.20, pFDR < 0.05), which predicted the level of depression in MDD (r = 0.45, p = 0.01, R2 = 0.15). In sum, we found a more integrated brain network in MDD patients with a lower nodal local efficiency at the occipital hub, which could predict depressive symptoms.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2022) conducted a case-control in Major depressive disorder (n=64). Major depressive disorder vs. Healthy controls was evaluated on Nodal local efficiency at the left middle occipital gyrus (p=pFDR < 0.05). Major depressive disorder was associated with significantly lower nodal local efficiency at the left middle occipital gyrus compared to healthy controls (0.56 vs. 0.81, pFDR < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: