Key result
Major depressive disorder was associated with significantly lower resting-state functional connectivity between the left dorsolateral prefrontal cortex and parietal lobe compared to healthy controls (Cohen's d 0.583).
Why the study?
To determine whether NIRS-based resting-state functional connectivity measurements can detect the connectivity abnormalities previously associated with major depressive disorder in fMRI studies.
Does NIRS-based resting-state functional connectivity differ between patients with major depressive disorder and healthy controls?
Case-Control (n=112)
No
Does NIRS-based resting-state functional connectivity differ between patients with major depressive disorder and healthy controls?
Standardized Mean Difference: 0.583 (95% CI 0.172–0.992)
Absolute Event Rate: 0.038% vs 0.171%
p-value: p=0.005
Whole-head NIRS can detect resting-state functional connectivity abnormalities in major depressive disorder, though the findings are preliminary and did not survive multiple comparison correction.
NIRS may detect MDD connectivity abnormalities; leaves open clinical utility pending replication and correction.
Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that has advantages in clinical usage. Previous functional magnetic resonance imaging (fMRI) studies have found that the resting-state functional connectivity (RSFC) of the default mode network (DMN) is increased, while the RSFC of the cognitive control network (CCN) is reduced in patients with major depressive disorder (MDD) compared with healthy controls. This study tested whether the NIRS-based RSFC measurements can detect the abnormalities in RSFC that have been associated with MDD in previous fMRI studies. We measured 8 min of resting-state brain activity in 34 individuals with MDD and 78 age- and gender-matched healthy controls using a whole-head NIRS system. We applied a previously established partial correlation analysis for estimating RSFCs between the 17 cortical regions. We found that MDD patients had a lower RSFC between the left dorsolateral prefrontal cortex and the parietal lobe that comprise the CCN, and a higher RSFC between the right orbitofrontal cortex and ventrolateral prefrontal cortex, compared to those in healthy controls. The RSFC strength of the left CCN was negatively correlated with the severity of depressive symptoms and the dose of antipsychotic medication and positively correlated with the level of social functioning. The results of this study suggest that NIRS-based measurements of RSFCs have potential clinical applications.
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Sakakibara et al. (2021) conducted a case-control in Major Depressive Disorder (n=112). Major Depressive Disorder vs. Healthy controls was evaluated on Resting-state functional connectivity (RSFC) between the left dorsolateral prefrontal cortex and parietal lobe (oxy-Hb) (Cohen's d 0.583, 95% CI 0.172-0.992, p=0.005). Major depressive disorder was associated with significantly lower resting-state functional connectivity between the left dorsolateral prefrontal cortex and parietal lobe compared to healthy controls (Cohen's d 0.583).
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