Key result
Outpatient treatment of worsening heart failure with intravenous or subcutaneous diuretics relieves symptoms with few adverse events, but heart failure re-hospitalization rates were 28% at 30 days.
Why the study?
Outpatient treatment of worsening HF with intravenous or subcutaneous diuretics has been proposed to prevent hospitalization amid rising HF prevalence and healthcare costs, but available evidence needed analysis.
Does outpatient treatment with intravenous or subcutaneous diuretics improve outcomes and prevent hospitalization in patients with worsening heart failure?
Population
984 unique individual patients with worsening HF across 11 studies
Comparison
Outpatient IV or subcutaneous diuretics vs hospitalization or head-to-head comparison
Authors
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Outpatient IV/SC diuretics for worsening HF warrant caution before adoption; leaves open need for RCTs to assess hospitalization prevention.
Systematic Review (n=984)
Does outpatient treatment with intravenous or subcutaneous diuretics improve outcomes and prevent hospitalization in patients with worsening heart failure?
Outpatient IV or SC diuretic treatment for worsening HF appears safe and relieves symptoms, but high-quality randomized trials are needed to confirm its impact on re-hospitalization and mortality.
Wierda et al. (2020) conducted a systematic review in Worsening heart failure (n=984). Outpatient intravenous or subcutaneous diuretics was evaluated on Re-hospitalization rates for heart failure. Outpatient treatment of worsening heart failure with intravenous or subcutaneous diuretics relieves symptoms with few adverse events, but heart failure re-hospitalization rates were 28% at 30 days.
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