Key result
Pregnant women with pulmonary hypertension experienced significantly higher major adverse cardiac events during delivery hospitalization compared to those without PH (24.8% vs 0.4%, P<0.0001).
Why the study?
Does pulmonary hypertension increase the risk of major adverse cardiac events and adverse pregnancy outcomes in pregnant women during delivery hospitalization?
Population
Pregnant women delivering during the years 2003 to 2012, including 1,519 patients with pulmonary…
Comparison
Presence of pulmonary hypertension and its… vs Women without heart disease or pulmonary…
Design
Cohort
Follow-up
During hospitalization for delivery
Authors
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PH in pregnancy signals high peripartum MACE risk, especially with cardiomyopathy; leaves open whether specialized care improves outcomes.
Observational (n=6,759,101)
Yes
Does pulmonary hypertension increase the risk of major adverse cardiac events and adverse pregnancy outcomes in pregnant women during delivery hospitalization?
Absolute Event Rate: 24.8% vs 0.4%
p-value: p=<0.0001
Pulmonary hypertension in pregnant women is associated with a markedly increased risk of major adverse cardiac events during delivery hospitalization, particularly when associated with cardiomyopathy.
Thomas et al. (2017) conducted an observational in Pulmonary hypertension in pregnancy (n=6,759,101). Pulmonary hypertension vs. No heart disease or pulmonary hypertension was evaluated on MACE, a composite of death, cardiac arrest, cardiogenic shock, myocardial infarction, respiratory failure, arrhythmia, stroke, and embolic event (p=<0.0001). Pregnant women with pulmonary hypertension experienced significantly higher major adverse cardiac events during delivery hospitalization compared to those without PH (24.8% vs 0.4%, P<0.0001).
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