Key result
A new hypothermal method successfully produced controlled myocardial lesions with complete necrosis of muscle cells, allowing selective placement in any cardiac chamber or the interventricular septum.
A novel hypothermal method allows for the precise, controlled production of myocardial lesions to study heart failure and conduction abnormalities in experimental models.
Supports experimental models of selective myocardial necrosis; leaves open clinical translation for arrhythmia or insufficiency studies.
Following a review of experimental methods used for the production of necrosis or inactivation of the myocardium, a new method employing low temperatures is described. Lesions, with complete necrosis of muscle cells, can be controlled as to size and can be selectively placed to involve any of the four cardiac chambers and the interventricular septum. This facilitates attempts to study chronic myocardial insufficiency in terms of quantity and location of damaged muscle. Also, it has been possible to produce disturbances in conduction by production of small interventricular septal lesions. Refined electrocardiographic analysis of the magnitude and location of ventricular lesions has not been possible.
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Taylor et al. (1951) studied Myocardial injury. Hypothermal method was evaluated on Production of controlled myocardial lesions. A new hypothermal method successfully produced controlled myocardial lesions with complete necrosis of muscle cells, allowing selective placement in any cardiac chamber or the interventricular septum.
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