Why the study?
Does hypothermic ischemic arrest affect myocardial contractility differently in hypertrophied versus nonhypertrophied canine left ventricles?
Does hypothermic ischemic arrest affect myocardial contractility differently in hypertrophied versus nonhypertrophied canine left ventricles?
Hypertrophied left ventricles are more vulnerable to ischemia during hypothermic arrest than nonhypertrophied ventricles, suggesting a need for enhanced myocardial protection.
Hypertrophied myocardium may need enhanced protection during hypothermic arrest; animal data leaves open clinical translation.
The effect of hypothermic ischemic arrest on myocardial contractility was investigated with use of isolated blood-perfused canine heart preparation in the hypertrophied left ventricle created by supravalvular aortic stenosis and the nonhypertrophied ventricle. The following results were obtained : The percent recovery rate of net developed tension during reperfusion after an ischemic period of 150 minutes at the myocardial temperature of 17°C was 90±9% in the nonhypertrophied muscle, while it was 70±19% in the hypertrophied muscle, that is, hypertrophied left ventricle was considered to be more vulnerable to ischemia as compared to nonhypertrophied left ventricle, suggesting the necessity of more intense myocardial protection in addition to cardiac hypothermia against ischemia in the hypertrophied heart.
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Mizutani et al. (1980) studied this question.
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