Why the study?
Does topical hypothermia protect myocardial contractility during anoxic arrest in isolated canine left ventricular muscle?
Population
Isolated blood-perfused electrically driven canine left ventricular muscle
Comparison
Hypothermic anoxic arrest vs Baseline (before hypothermic anoxic arrest)
Design
Preclinical
Authors
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Defines 90-min safe anoxic arrest at 17°C in canine myocardium; leaves open translation to clinical protection strategies.
Does topical hypothermia protect myocardial contractility during anoxic arrest in isolated canine left ventricular muscle?
In an isolated canine left ventricular muscle model, the safe limit of acute anoxia at 17 degrees C is 90 minutes, with full recovery of myocardial contractility.
Shida et al. (1979) studied this question.
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