Key result
Hypertrophied left ventricles were more vulnerable to 150 minutes of hypothermic ischemia (17°C) compared to non-hypertrophied ventricles, which had a 90% recovery rate of net developed tension.
Why the study?
Does hypothermic ischemic arrest affect myocardial contractility differently in hypertrophied versus non-hypertrophied canine ventricles?
Does hypothermic ischemic arrest affect myocardial contractility differently in hypertrophied versus non-hypertrophied canine ventricles?
Hypertrophied left ventricles are more vulnerable to ischemia during hypothermic arrest than non-hypertrophied ventricles, suggesting a need for enhanced myocardial protection strategies during cardiac surgery.
Answers are grounded in this paper and cite their sources.
Hypertrophied ventricles may need tailored protection during hypothermic arrest; leaves open translation to human cardiac surgery.
The effect of hypothermic ischemic arrest on myocardial contractility was investigated with use of isolated blood-perfused canine heart preparation in the hypertrophied left ventricle created by supravascular aortic stenosis and the non-hypertrophied ventricle. The following results were obtained: The percent recovery rate of net developed tension during reperfusion after an ischemic period of 150 minutes at the myocardial temperature of 17 degrees C was 90 +/- 9% in the non-hypertrophied muscle, that is, hypertrophied left ventricle was considered to be more vulnerable to ischemia as compared to nonhypertrophied left ventricle, suggesting the necessity of more intense myocardial protection in addition to cardiac hypothermia against ischemia in the hypertrophied heart.
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Shida et al. (1980) studied Hypertrophied left ventricle. Hypertrophied left ventricle vs. Non-hypertrophied left ventricle was evaluated on Percent recovery rate of net developed tension during reperfusion. Hypertrophied left ventricles were more vulnerable to 150 minutes of hypothermic ischemia (17°C) compared to non-hypertrophied ventricles, which had a 90% recovery rate of net developed tension.
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