Key result
Continuous coronary perfusion with diluted cooled blood maintained significantly higher myocardial ATP content after 90 minutes of ischemic arrest compared to other protection methods (p<0.01).
Why the study?
Which myocardial protection method best preserves left ventricular function and myocardial metabolism in an isolated working canine heart model?
Population
Isolated hearts from 56 normal adult mongrel dogs (8-12 kg)
Comparison
Five methods of myocardial protection applied… vs Control group
Design
Preclinical
Follow-up
Up to 90 minutes
Authors
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Hypothesis-generating for myocardial protection strategies; should not change clinical practice.
Which myocardial protection method best preserves left ventricular function and myocardial metabolism in an isolated working canine heart model?
p-value: p=<0.01
In a canine isolated heart model, continuous coronary perfusion with diluted blood provided the best preservation of myocardial ATP content during ischemic arrest compared to surface cooling and other cardioplegic solutions.
Tsutomu Osako (1984) studied Myocardial protection during ischemic arrest (n=56). Continuous coronary perfusion with diluted cooled blood vs. Surface cooling, intermittent lactated Ringer's, potassium cardioplegia, and GIK perfusion was evaluated on Myocardial ATP content at 90 minutes (µmol/g wet weight) (p=<0.01). Continuous coronary perfusion with diluted cooled blood maintained significantly higher myocardial ATP content after 90 minutes of ischemic arrest compared to other protection methods (p<0.01).
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