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January 1, 1974ThoraxOpen Access

An experimental evaluation of continuous normothermic, intermittent hypothermic, and intermittent normothermic coronary perfusion

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Why the study?

Does continuous normothermic perfusion improve myocardial maintenance compared to intermittent hypothermic or normothermic perfusion in isolated canine hearts?

Population

Isolated, cross-perfused canine hearts

Comparison

Continuous normothermic coronary perfusion vs Intermittent hypothermic and intermittent…

Design

Preclinical

Follow-up

2 hours

Authors

ABA. H. BrownUK Energy Research CentreMBM.V. BraimbridgeSt Thomas' HospitalSDSally DarracottSt Thomas' Hospital

Discussion

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Implication

Continuous normothermic perfusion shows promise in canine models; leaves open clinical translation pending human studies.

Structured PICO

Does continuous normothermic perfusion improve myocardial maintenance compared to intermittent hypothermic or normothermic perfusion in isolated canine hearts?

P
Population
Isolated, cross-perfused canine hearts
I
Intervention
Continuous normothermic coronary perfusion
C
Comparator
Intermittent hypothermic and intermittent normothermic coronary perfusion
O
Outcome
Myocardial function and cellular preservation (isovolumic function, succinic dehydrogenase distribution, freed phospholipids, ATP response of myosin, ventricular edema) over two hourssurrogate

Continuous normothermic perfusion provides better myocardial maintenance than intermittent perfusion, though moderate hypothermia ameliorates the effects of intermittent ischemia.

Cite This Study

Brown et al. (1974) studied this question.

synapsesocial.com/papers/6a75c3fb74b63c188eb1f441https://doi.org/10.1136/thx.29.1.38
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial damage and valve replacements1971 · 12 citations
  2. 2Experimental Comparison of Methods for Protecting the Heart During Aortic Occlusion1962 · 86 citations
  3. 3Factors Which Initiate or Influence Edema in the Isolated Dog's Heart1961 · 35 citations