Key result
An increasing systolic BP trajectory over time without reaching the hypertension threshold was associated with a 1.57-fold higher risk of incident CKD compared with a stable trajectory.
Why the study?
It was unknown whether systolic BP that rises over time without reaching the hypertension threshold can impair kidney function in persons without hypertension.
Does an increasing systolic BP trajectory increase the risk of incident CKD in adults without hypertension or CKD?
Cohort (n=4,643)
Yes
Does an increasing systolic BP trajectory increase the risk of incident CKD in adults without hypertension or CKD?
Hazard Ratio: 1.57 (95% CI 1.2–2.06)
Absolute Event Rate: 17.8% vs 9.6%
p-value: p=0.001
An increasing systolic BP trajectory over time, even without reaching the hypertension threshold, is associated with a significantly increased risk of incident CKD in healthy adults.
No takes yet. Share an insight, caveat, or question.
May identify normotensives at higher CKD risk via rising BP trajectories; leaves open whether early intervention alters outcomes.
Joo et al. (2020) conducted a cohort in Without CKD and hypertension (n=4,643). Increasing systolic BP trajectory vs. Stable systolic BP trajectory was evaluated on Incident CKD development (two consecutive eGFR <60 ml/min per 1.73 m2) (HR 1.57, 95% CI 1.20-2.06, p=0.001). An increasing systolic BP trajectory over time without reaching the hypertension threshold was associated with a 1.57-fold higher risk of incident CKD compared with a stable trajectory.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: