Diminished tolerance of prehypertrophic, cardiomyopathic Syrian hamster hearts to Ca2+ stresses.
Key result
Prehypertrophic cardiomyopathic hamster hearts showed a lower threshold for Ca2+ overload in response to increased extracellular Ca2+ and adrenergic or Ca2+ channel agonists compared to controls.
Population
Isolated perfused hearts from 24-45-day-old male cardiomyopathic Syrian hamsters, BIO 14.6 strain, and age…
Comparison
Ca2+ stresses including increases in perfusate… vs Age- and sex-matched F1B strain control hamster…
Design
Preclinical
Authors
Discussion
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Implication
Prehypertrophic Ca2+ tolerance in CMH hearts remains untested clinically; leaves open whether early calcium dysregulation initiates cardiomyopathy.
Structured PICO
P
Population
Isolated perfused hearts from 24-45-day-old male cardiomyopathic hamsters and age-matched controls.
I
Intervention
Ca2+ stresses including increases in perfusate [Ca2+] (Cao), the Ca2+ channel agonist Bay K 8644, and alpha- or beta-adrenergic agonists.
C
Comparator
Age- and sex-matched F1B strain control hamster hearts subjected to the same stresses.
O
Outcome
Isovolumic contractile function (end-diastolic pressure, developed pressure, half relaxation time) and scattered laser light intensity fluctuation (SLIF).surrogate
Prehypertrophic cardiomyopathic Syrian hamster hearts exhibit a diminished tolerance to calcium stresses, indicating early abnormalities in calcium homeostasis before the onset of hypertrophy.
Cite This Study
Hano et al. (1991) studied Cardiomyopathy (prehypertrophic stage). Ca2+ stresses (increased perfusate [Ca2+], Bay K 8644, alpha- or beta-adrenergic agonists) vs. F1B strain controls was evaluated on Isovolumic contractile function and Ca2+ overload profile. Prehypertrophic cardiomyopathic hamster hearts showed a lower threshold for Ca2+ overload in response to increased extracellular Ca2+ and adrenergic or Ca2+ channel agonists compared to controls.