Key result
Bio TO-2 cardiomyopathic hamsters progressively develop altered cardiac function with lower mean arterial pressure (-22%) and cardiac output (-34%) alongside cardiac remodeling and LV dilation.
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Offers no immediate clinical guidance; extends Bio TO-2 hamster model characterization for future translational studies.
Goineau et al. (2001) studied Dilated cardiomyopathy (n=80). Bio TO-2 strain (cardiomyopathic hamsters) vs. Controls was evaluated on Hemodynamic and histomorphometric characteristics. Bio TO-2 cardiomyopathic hamsters progressively develop altered cardiac function with lower mean arterial pressure (-22%) and cardiac output (-34%) alongside cardiac remodeling and LV dilation.
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