Why the study?
Does verapamil or hydralazine prevent microcirculatory disorders and myocytolysis in cardiomyopathic Syrian hamsters?
Population
45 cardiomyopathic Syrian hamsters and 18 control hamsters
Comparison
Verapamil or hydralazine vs Untreated cardiomyopathic hamsters and healthy…
Design
Preclinical
Follow-up
Evaluated at 30 and 44 days of age
Authors
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Hypothesis-generating for microcirculatory therapy in cardiomyopathy; requires human studies before clinical consideration.
Does verapamil or hydralazine prevent microcirculatory disorders and myocytolysis in cardiomyopathic Syrian hamsters?
In a hamster model of cardiomyopathy, microcirculatory disorders generate tissue damage that can be prevented by treatment with verapamil or hydralazine.
Figulla et al. (1987) studied this question.