Key result
Isoproterenol interfered with the development and progression of hamster hereditary polymyopathy, providing cytoprotection to skeletal and heart muscles and reducing serum creatine kinase.
Why the study?
Does isoproterenol improve muscle pathology in hamster hereditary polymyopathy?
Does isoproterenol improve muscle pathology in hamster hereditary polymyopathy?
Isoproterenol paradoxically exerts a cytoprotective effect on skeletal and heart muscles in hamster hereditary polymyopathy, suggesting the role of calcium in this disease should be re-evaluated.
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Should not change myopathy management; leaves open beta-agonist investigation in human cardiomyopathy models.
Jasmin et al. (1983) studied Hamster hereditary polymyopathy. Isoproterenol was evaluated on Development and progression of hamster hereditary polymyopathy. Isoproterenol interfered with the development and progression of hamster hereditary polymyopathy, providing cytoprotection to skeletal and heart muscles and reducing serum creatine kinase.
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