Metformin: its botanical background

This article traces the roots of the antihyperglycaemic biguanide metformin from the use of Galega officinalis (goat's rue or French lilac) as a herbal treatment for the symptoms of diabetes. G. officinalis was found to be rich in guanidine, a substance with blood glucose‐lowering activity that formed the chemical basis of metformin. This insulin sensitising drug was introduced in 1957.