Key result
Acyanotic congenital heart disease with a high velocity jet, such as ventricular septal defects, should be considered for peri-procedural antibiotic prophylaxis for infective endocarditis.
Why the study?
Does peri-procedural antibiotic prophylaxis prevent infective endocarditis in patients with acyanotic congenital heart disease with high velocity jet (e.g., VSD)?
Case Report
Does peri-procedural antibiotic prophylaxis prevent infective endocarditis in patients with acyanotic congenital heart disease with high velocity jet (e.g., VSD)?
This case study challenges current AHA/ACC guidelines by suggesting that patients with acyanotic congenital heart disease and high velocity jets, such as VSDs, may benefit from peri-procedural antibiotic prophylaxis for infective endocarditis.
Case report does not support changing prophylaxis guidelines; hypothesis-generating for prospective VSD trials.
The current American Heart Association (AHA)/American College of Cardiology (ACC) guidelines do not recommend antibiotic prophylaxis for infective endocarditis (IE) in patients with acyanotic congenital valvular heart disease due to lack of any proven benefit and potential harm associated with antibiotics. As recognized by the guidelines, some acyanotic congenital heart disease, such as ventricular septal defects (VSDs), are associated with a high velocity jet and pose a greater risk of peri-procedural endocarditis. We suggest that an acyanotic congenital heart disease with high velocity jet should be considered for antibiotic prophylaxis for IE.
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Garg et al. (2018) conducted a case report in Ventricular septal defect / Acyanotic congenital heart disease. Peri-procedural antibiotic prophylaxis was evaluated on Infective endocarditis. Acyanotic congenital heart disease with a high velocity jet, such as ventricular septal defects, should be considered for peri-procedural antibiotic prophylaxis for infective endocarditis.
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