Key result
Percutaneous transvenous mitral commissurotomy significantly improved right ventricular function immediately post-procedure, including a reduction in the RV Tei index from 0.56 to 0.40.
Why the study?
Does percutaneous transmitral commissurotomy improve right ventricular function in patients with rheumatic mitral stenosis?
Cross-Sectional (n=50)
No
Does percutaneous transmitral commissurotomy improve right ventricular function in patients with rheumatic mitral stenosis?
Mean Difference: -0.15 (95% CI -0.19–-0.12)
Absolute Event Rate: 0.4% vs 0.56%
p-value: p=< 0.001
Successful percutaneous transmitral commissurotomy in patients with rheumatic mitral stenosis leads to immediate improvements in right ventricular function and pulmonary artery systolic pressure.
Background and Aims: Abnormal Right Ventricular (RV) function affects the long term outcome and clinical symptoms in patients with mitral stenosis (MS). This study evaluates the immediate effect of Percutaneous Transmitral Commisurotomy (PTMC) on RV function.Methods: An observational, cross sectional study was done on 50 patients with rheumatic MS who underwent PTMC at Shahid Gangalal National Heart Center from Dec 2015 –Dec 2016. All underwent clinical evaluation and echocardiogram before and immediately after PTMC.Results: There was female preponderance with 66% being female. The mean age was 37.26 ± 10.63 years. There was immediate increase in the mitral valve area (MVA) from 0.87 ± 0.12cm2 to 1.54 ± 0.27cm2(p< 0.001). There was significant decrease in mean mitral diastolic gradient from 16.4 ± 8.8mmHg to 5 ± 1.5mmHg (p< 0.001), in the pulmonary artery systolic pressure 53.6 ± 21.83mmHg to 39.5 ± 14.67mmHg (p< 0.001), in the RV Tei index from 0.56 ± 0.08 to 0.40 ± 0.08 (p< 0.001). There was significant increase in TAPSE from 16.0 ± 1.50 to 18.6 ± 1.70 mm, (p<0.001) and the longitudinal velocity of excursion of the RV at the tricuspid annulus (RV S’) from 13.69 ± 3.33 cm/sec to 15.31 ± 3.07 cm/sec (p< 0.001)Conclusions: Successful PTMC can improve RV function as shown by the improvement in PASP, RV Tei index, TAPSE and RV S’. Further larger population studies are required to confirm the findings. Long term studies are important to determine the prognostic significance of improvement in RV function.
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KC et al. (2017) conducted a cross-sectional in Rheumatic Mitral Stenosis (n=50). Percutaneous Transvenous Mitral Commissurotomy (PTMC) vs. Pre-PTMC baseline was evaluated on RV Tei index (MD -0.15, 95% CI -0.19 to -0.12, p=< 0.001). Percutaneous transvenous mitral commissurotomy significantly improved right ventricular function immediately post-procedure, including a reduction in the RV Tei index from 0.56 to 0.40.
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