Key result
The Carmeda-coated oxygenator resulted in a 3.6% net platelet count drop at 15-20 minutes of bypass compared to 6.2% with the Trillium-coated oxygenator, with no significant difference.
Why the study?
Does a Carmeda-coated oxygenator reduce circulating platelet count drop compared to a Trillium-coated oxygenator in patients undergoing non-emergency myocardial revascularization during cardiopulmonary bypass?
RCT (n=60)
Randomly divided
Does a Carmeda-coated oxygenator reduce circulating platelet count drop compared to a Trillium-coated oxygenator in patients undergoing non-emergency myocardial revascularization during cardiopulmonary bypass?
Both Carmeda-coated and Trillium-coated oxygenators provide similar preservation of circulating platelet counts during cardiopulmonary bypass for non-emergency myocardial revascularization.
Both coatings yield similar platelet preservation during CPB; leaves open outcome benefits versus uncoated circuits.
An investigation was conducted to evaluate the effect that surface coating of the hollow-fiber membrane oxygenator had on circulating platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing non-emergency myocardial revascularization for coronary artery disease were randomly divided into two groups. Group one (n = 32) received the Carmeda-coated Maxima-Plus PRF oxygenator while the patients in Group two (n=28) received the Trillium-coated Affinity oxygenator during CPB. The net platelet count drops for the pump specimen (15-20 min after the initiation of bypass) for the Carmeda and the Trillium groups were 3.6 +/- 15.8% and 6.2 +/- 10.2%, respectively. The net platelet count drop for the warming specimen for the Carmeda and the Trillium groups were 2.9 +/- 19.4% and 0.5 +/- 11.0%, respectively. There were no statistically significant differences between the groups. The authors conclude that using either the Carmeda-coated Maxima-Plus PRF oxygenator or the Trillium-coated Affinity oxygenator afford similar benefits in regards to preserving circulating platelet counts during bypass.
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Palanzo et al. (2001) conducted an RCT in Coronary artery disease (n=60). Carmeda-coated Maxima-Plus PRF oxygenator vs. Trillium-coated Affinity oxygenator was evaluated on Net platelet count drop for the pump specimen (15-20 min after the initiation of bypass). The Carmeda-coated oxygenator resulted in a 3.6% net platelet count drop at 15-20 minutes of bypass compared to 6.2% with the Trillium-coated oxygenator, with no significant difference.
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