IN this paper experiments are described which show that ketonic acids can react in animal tissues according to the general scheme R. CO.COOH + R'. CO. COOH + H20-R. COOH + C02 + R'. CH(OH). COOH ...... (1) oa-ketonic a-ketonic carboxylic a-hydroxy-acid acid I acid II acid or R. CO. COOH + R'. CO . CH2. COOH + H20-R. COOH + CO2 + R'. CH(OH) .C0. COOH ....(2). ae-ketonic fl-ketonic acid carboxylic ,-hydroxy-acid acid acid
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Krebs et al. (1937) studied this question.
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