What question did this study set out to answer?

To investigate how sympathetic input from the SCN influences the phase of gene expression in peripheral oscillators, particularly in the submaxillary gland.

April 23, 2008AJP Regulatory Integrative and Comparative PhysiologyOpen Access

Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators

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To investigate how sympathetic input from the SCN influences the phase of gene expression in peripheral oscillators, particularly in the submaxillary gland.
Used a model of daytime-restricted feeding in rats
Performed sympathetic denervation of the submaxillary glands
Measured expression of the clock gene Period1 (Per1) in response to feeding cues
After sympathetic denervation, submaxillary Per1 rhythms shifted phase 180 degrees
Gland rhythms entrained to daytime feeding schedules following denervation
Underscored that multiple signals, including sympathetic innervation and feeding cues, affect oscillator phase

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Implication

Randomized trial assesses how sympathetic input influences circadian rhythms in peripheral tissues, indicating complexity of phase control mechanisms.

Cite This Study

Vujović et al. (2008) studied this question.

synapsesocial.com/papers/6a61a131dcbd73a1130a77ca https://doi.org/10.1152/ajpregu.00498.2007

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Implication

Randomized trial assesses how sympathetic input influences circadian rhythms in peripheral tissues, indicating complexity of phase control mechanisms.

Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators

Key Points

Discussion

Implication

Cite This Study

Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators

Key Points

Discussion

Implication

Cite This Study

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