Population
Animal model (implied) undergoing suprachiasmatic nucleus (SCN) lesion or hepatic sympathectomy
Comparison
Hepatic sympathectomy combined with a six-meal… vs Six-meal feeding schedule without hepatic…
Design
Preclinical
Authors
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Hepatic sympathetic input may drive glucose rhythmicity independently of liver clocks in rodents; leaves open translation to human circadian metabolism.
The suprachiasmatic nucleus requires the sympathetic pathway to the liver to generate the 24-hour rhythm in plasma glucose concentrations, which is independent of hepatic clock-gene rhythmicity.
Cailotto et al. (2005) studied this question.
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