Key result
Bilateral lesions of the suprachiasmatic nucleus abolished the daily rhythms of plasma glucose, FFA, insulin, and glucagon concentrations in rats.
Why the study?
Does bilateral lesion of the SCN alter daily rhythms of plasma glucose, FFA, insulin, and glucagon in rats?
Population
Rats under 12 hr-12 hr light-dark conditions
Comparison
Bilateral lesions of the suprachiasmatic nucleus vs Sham-operated rats
Design
Preclinical
Authors
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SCN is required for metabolic rhythms in rats; leaves open translation to human circadian-metabolic disorders.
Does bilateral lesion of the SCN alter daily rhythms of plasma glucose, FFA, insulin, and glucagon in rats?
The suprachiasmatic nucleus is essential for generating daily rhythms in plasma glucose, FFA, insulin, and glucagon, and regulates pancreatic hormone secretion in rats.
Yamamoto et al. (1987) studied this question. Bilateral lesions of the suprachiasmatic nucleus (SCN) vs. Sham-operated rats was evaluated on Daily rhythms of plasma glucose, FFA, insulin and glucagon concentrations. Bilateral lesions of the suprachiasmatic nucleus abolished the daily rhythms of plasma glucose, FFA, insulin, and glucagon concentrations in rats.