Key result
Unilateral hepatic denervation (sympathectomy or parasympathectomy) abolished the plasma glucose rhythm, whereas complete removal of autonomic inputs did not impair the rhythm.
Population
Animal model
Design
Preclinical
Authors
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Challenges prior emphasis on hepatic sympathetic innervation for glucose rhythms; leaves open central mechanisms driving daily variation.
An unbalanced autonomic nervous system output to the liver disrupts daily plasma glucose rhythms, suggesting a mechanism for disturbed glucose balance in obesity and diabetes.
Cailotto et al. (2007) studied this question. Hepatic denervation (complete, sympathetic, or parasympathetic) vs. Intact autonomic inputs was evaluated on Plasma glucose rhythm and daily expression of glucoregulatory enzymes. Unilateral hepatic denervation (sympathectomy or parasympathectomy) abolished the plasma glucose rhythm, whereas complete removal of autonomic inputs did not impair the rhythm.
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