Key result
High-resolution MRI with cardiac and respiratory gating showed excellent agreement with cross-sectional histopathology for measuring aortic vessel wall area in mice.
Why the study?
Does high-resolution MRI with cardiac and respiratory gating accurately visualize atherosclerotic plaques in apolipoprotein-E deficient mice compared to histopathology?
Does high-resolution MRI with cardiac and respiratory gating accurately visualize atherosclerotic plaques in apolipoprotein-E deficient mice compared to histopathology?
High-resolution MRI with cardiac and respiratory gating provides accurate in vivo visualization of atherosclerotic plaques in mice, showing excellent agreement with histopathology.
Answers are grounded in this paper and cite their sources.
MRI plaque imaging is feasible in apoE-deficient mice; leaves open its utility for longitudinal mechanistic atherosclerosis studies.
Genetically engineered mouse models provide enormous potential for investigation of the underlying mechanisms of atherosclerotic disease, but noninvasive imaging methods for analysis of atherosclerosis in mice are currently limited. This study aimed to demonstrate the feasibility of MRI to noninvasively visualize atherosclerotic plaques in the thoracic aorta in mice deficient in apolipoprotein-E, who develop atherosclerotic lesions similar to those observed in humans. To freeze motion, MR data acquisition was both ECG- and respiratory-gated. T(1)-weighted MR images were acquired with TR/TE approximately 1000/10 ms. Spatial image resolution was 49 x 98 x 300 micro m(3). MRI revealed a detailed view of the lumen and the vessel wall of the entire thoracic aorta. Comparison of MRI with corresponding cross-sectional histopathology showed excellent agreement of aortic vessel wall area (r = 0.97). Hence, noninvasive MRI should allow new insights into the mechanisms involved in progression and regression of atherosclerotic disease.
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Wiesmann et al. (2003) studied Atherosclerosis. High-resolution MRI with cardiac and respiratory gating vs. Cross-sectional histopathology was evaluated on Agreement of aortic vessel wall area between MRI and histopathology (r = 0.97). High-resolution MRI with cardiac and respiratory gating showed excellent agreement with cross-sectional histopathology for measuring aortic vessel wall area in mice.
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