Differential response to right and left ansae subclaviae stimulation of early afterdepolarizations and ventricular tachycardia induced by cesium in dogs.
Key result
Left and bilateral ansae subclaviae stimulation produced larger left ventricular early afterdepolarizations and more frequent ventricular tachycardia (16/20 and 12/20 dogs) than cesium alone (6/20).
Why the study?
Does left versus right ansae subclaviae stimulation differentially affect early afterdepolarizations and ventricular tachycardia induced by cesium in dogs?
Population
20 open-chest dogs
Comparison
Cesium chloride combined with left, right, or… vs Cesium chloride alone, and comparison between…
Design
Preclinical
Authors
Discussion
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Implication
Left ansae subclaviae stimulation amplifies cesium-induced EADs and VT in dogs; hypothesis-generating for asymmetric sympathetic targeting in long QT.
Key Points
- This study aims to examine how right and left ansae subclaviae stimulation affects early afterdepolarizations (EADs) and ventricular tachycardia (VT) in dogs.
- Conducted experiments on 20 open-chest dogs using cesium chloride and sympathetic stimulation at various sites.
- Measured EAD amplitude and area in the left and right ventricles during different stimulation conditions.
- Induced VT and assessed its prevalence relative to different stimulation protocols.
- Bilateral and left ansae subclaviae stimulation produced larger EADs in the left ventricle compared to right ansae or cesium alone.
- VT was induced in 16 of 20 dogs during left ansae stimulation and in 12 during bilateral stimulation, while cesium alone induced VT in 6 dogs.
- Norepinephrine infusion increased EAD amplitudes equally in both ventricles, indicating consistent responsiveness to catecholamines.
Structured PICO
Does left versus right ansae subclaviae stimulation differentially affect early afterdepolarizations and ventricular tachycardia induced by cesium in dogs?
P
Population
20 open-chest dogs studied for the effects of sympathetic stimulation on early afterdepolarizations and ventricular tachycardia produced with cesium chloride.
I
Intervention
Cesium chloride (84 mg/kg i.v.) combined with left (LAS), right (RAS), or bilateral (BAS) ansae subclaviae stimulation (2 Hz, 4 msec, 2 mA), or norepinephrine infusion (0.1-1.5 micrograms/kg/min)
C
Comparator
Cesium chloride alone, and comparison between different stimulation sites (LAS vs RAS vs BAS)
O
Outcome
Early afterdepolarization (EAD) amplitude and area as a percentage of monophasic action potential amplitude and area, and prevalence of ventricular tachycardia (VT) inductionsurrogate
Left stellate ganglion stimulation produces larger early afterdepolarizations in the left ventricle and more frequent ventricular tachycardia compared to right stimulation in a canine model of cesium-induced long QT syndrome.
Cite This Study
Bendavid et al. (1988) studied Early afterdepolarizations and ventricular tachycardia (n=20). Left, right, or bilateral ansae subclaviae stimulation vs. Cesium chloride alone was evaluated on EAD amplitude and area, and prevalence of VT induction. Left and bilateral ansae subclaviae stimulation produced larger left ventricular early afterdepolarizations and more frequent ventricular tachycardia (16/20 and 12/20 dogs) than cesium alone (6/20).