Automated Global Longitudinal Strain Assessment in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia
Key result
Automated global longitudinal strain detected a higher prevalence of left ventricular systolic dysfunction than LVEF (26.6% vs. 12.2%) in long-term childhood acute lymphoblastic leukemia survivors.
Why the study?
Evidence supporting the use of global longitudinal strain in long-term cardiac monitoring of childhood acute lymphoblastic leukemia survivors is limited.
Does automated GLS assessment improve the detection of left ventricular systolic dysfunction compared to LVEF in long-term survivors of childhood acute lymphoblastic leukemia?
Comparison
Childhood acute lymphoblastic leukemia survivors vs controls, and automated GLS vs LVEF
Design
Observational cohort study with inverse probability weighting
Follow-up
Median 18 (11−26) years
Authors
Discussion
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Member takes
Implication
GLS may detect subclinical LVSD in long-term CLSs; leaves open its role in routine surveillance.
Study Design
Type
Observational (n=90)
Structured PICO
Does automated GLS assessment improve the detection of left ventricular systolic dysfunction compared to LVEF in long-term survivors of childhood acute lymphoblastic leukemia?
P
Population
90 long-term survivors of childhood acute lymphoblastic leukemia with a median follow-up of 18 years.
E
Exposure
Automated global longitudinal strain (GLS) assessment
C
Comparator
Left ventricular ejection fraction (LVEF) assessment and a control group
O
Outcome
Detection of left ventricular systolic dysfunction (LVSD), defined as asymptomatic (LVEF < 50%) or subclinical (GLS < 18.5%)surrogate
Main Result
Absolute Event Rate: 26.6% vs 12.2%
Automated GLS detects subclinical left ventricular systolic dysfunction more frequently than standard LVEF in long-term survivors of childhood leukemia, highlighting its potential utility in routine cardio-oncology surveillance.
Cite This Study
Manzanares et al. (2022) conducted an observational in Childhood acute lymphoblastic leukemia (n=90). Automated global longitudinal strain (GLS) vs. Left ventricular ejection fraction (LVEF) was evaluated on Detection of left ventricular systolic dysfunction (LVSD). Automated global longitudinal strain detected a higher prevalence of left ventricular systolic dysfunction than LVEF (26.6% vs. 12.2%) in long-term childhood acute lymphoblastic leukemia survivors.