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This case examines a rare presentation of pernicious anemia that mimics thrombotic thrombocytopenic purpura.

July 23, 2026CureusOpen Access

Pernicious Anemia Mimicking Thrombotic Thrombocytopenic Purpura in the Setting of Severe Vitamin B12 Deficiency

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Case report reveals pernicious anemia mimicking thrombotic thrombocytopenic purpura, highlighting diagnosis implications.

This case examines a rare presentation of pernicious anemia that mimics thrombotic thrombocytopenic purpura.
Detailed patient evaluation including blood tests for anemia and hemolysis markers.
Diagnosis confirmed via elevated methylmalonic acid, homocysteine levels, and intrinsic factor antibodies.
Treatment involved vitamin B12 injections, folate, and supportive care.
Patient presented with profound macrocytosis and neurological deficits.
Rapid improvement was noted after administration of vitamin B12.
Diagnosis prevented unnecessary interventions for thrombotic microangiopathy.

Hrysikos et al. (2026) studied this question.

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July 23, 2026CureusOpen Access

View Full Paper

Ask AI

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Authors

Case report reveals pernicious anemia mimicking thrombotic thrombocytopenic purpura, highlighting diagnosis implications.

This case examines a rare presentation of pernicious anemia that mimics thrombotic thrombocytopenic purpura.
Detailed patient evaluation including blood tests for anemia and hemolysis markers.
Diagnosis confirmed via elevated methylmalonic acid, homocysteine levels, and intrinsic factor antibodies.
Treatment involved vitamin B12 injections, folate, and supportive care.
Patient presented with profound macrocytosis and neurological deficits.
Rapid improvement was noted after administration of vitamin B12.
Diagnosis prevented unnecessary interventions for thrombotic microangiopathy.

Hrysikos et al. (2026) studied this question.

View Full Paper

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