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This research aims to understand how exclusive enteral nutrition (EEN) affects inflammation and intestinal barrier function in a model of colitis.

Exclusive enteral nutrition containing transforming growth factor‐β improves intestinal barrier function in a colitis mouse model

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This research aims to understand how exclusive enteral nutrition (EEN) affects inflammation and intestinal barrier function in a model of colitis.
Mice were treated with dextran sulfate sodium (DSS) to induce colitis.
Two enteral nutrition formulas were compared, with specific evaluations on the effects of TGF-β through supplementation and inhibition.
Colonic crypts were cultured to analyze cellular properties.
Both EEN formulas led to improved weight recovery and disease activity index.
EEN with TGF-β resulted in faster weight recovery and decreased inflammation with normalized intestinal permeability.
Organoids from colonic crypts treated with TGF-β showed enhanced survival and re-epithelialization.

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Randomized trial explores how exclusive enteral nutrition improves intestinal health in a colitis model, indicating the importance of TGF-β.

Boumessid et al. (2026) studied this question.

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Randomized trial explores how exclusive enteral nutrition improves intestinal health in a colitis model, indicating the importance of TGF-β.