Orthopedic Surgery as a Risk Factor for Extracorporeal Circuit Coagulation in Patients on Hemodialysis: A Retrospective Observational Study

Aim This study aimed to investigate the clinical background associated with extracorporeal circuit coagulation (ECC) with a specific focus on the impact of orthopedic surgery. Methods A single‐center retrospective observational study of 290 hospitalized adult hemodialysis patients (men/women: 204/86, median age: 70 years) was included. Univariate and multivariate negative binomial regression analyses were performed to identify factors associated with ECC. Results Twenty‐five ECC events were observed in a total of 20 (6.8%) patients (men/women: 14/6). In univariate negative binomial regression analysis, orthopedic surgery was significantly associated with ECC (incidence rate ratio, 4.16; 95% confidence interval, 1.68–10.0, p = 0.001). In multivariate analysis, the performance of orthopedic surgery emerged as a potent and independent factor for an increased frequency of ECC. Conclusion Orthopedic surgery is significantly associated with an increased frequency of ECC. This finding highlights the importance of considering orthopedic surgery as a potential clinical factor for ECC in perioperative hemodialysis management.