Formal synthesis demonstrates effective transformations for producing 11-β-methoxycurvularin, suggesting new pathways for related natural products.
An efficient stereospecific protocol for the formal synthesis of benzannulated macrolactone 11-β-methoxycurvularin was established. The key transformations include the regioselective epoxide opening and Steglich esterification for the formation of the polyketide chain and intramolecular Friedel-Crafts acylation for macrocyclization, providing an efficient route toward the synthesis of related biologically active natural products.
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Kumar et al. (2026) studied this question.
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