Key result
Higher SBP, BMI, CAD, and T2D are genetically linked to increased cIMT.
Why the study?
Knowledge about the shared genetic basis of cIMT remains limited, and genetic determinants in non-European ancestry populations are largely understudied.
Population
22 370 participants from the China Kadoorie Biobank
Design
Genome-wide association study and cross-trait analysis
Authors
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Novel cIMT loci identified in non-Europeans; extends European GWAS but leaves clinical translation open.
Observational (n=22,370)
Yes
This large-scale GWAS identified novel genetic loci for cIMT in a Chinese population and demonstrated shared genetic architecture and causal relationships between cIMT and cardiometabolic traits.
Wang et al. (2026) conducted an observational in Carotid artery intima-media thickness (n=22,370). Cardiometabolic diseases and traits was evaluated on Genetic associations and causal relationships with cIMT. Mendelian randomization indicated that higher systolic blood pressure, body mass index, coronary artery disease, and type 2 diabetes were causally associated with carotid intima-media thickness.
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