Hesperetin and Isoliquiritigenin Ameliorates the Hepatic and Renal Complications in Type 2 Diabetic Rats

Meenu; Mohd Aqil; Syed Ehtaisham Ul Haque; Mohd Akhtar; Mohd Mujeeb; Zehra Zaidi; Mohd Vaseem Ismail; Abul Kalam Najmi

doi:10.1177/0976500x261463364

July 21, 2026Journal of Pharmacology and PharmacotherapeuticsOpen Access

Hesperetin and Isoliquiritigenin Ameliorates the Hepatic and Renal Complications in Type 2 Diabetic Rats

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Key Points

This study aims to evaluate the effects of hesperetin and isoliquiritigenin on liver and kidney complications in type 2 diabetic rats.
Type 2 diabetes was induced in Wistar rats using a high-fat diet and streptozotocin injection.
Rats were treated orally with hesperetin (50 and 100 mg/kg), isoliquiritigenin (10 and 20 mg/kg), or empagliflozin (30 mg/kg) for 4 weeks.
Biochemical markers, blood glucose, and liver histology were assessed post-treatment.
Hesperetin and isoliquiritigenin significantly normalized biochemical markers and risk indexes in diabetic rats.
Treatment reduced blood glucose levels and improved beta-cell function, indicated by decreased HOMA-β levels.
Biochemical indicators of liver damage and oxidative stress were improved, alongside normalization of cytokine levels.

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Implication

Assesses hesperetin and isoliquiritigenin's effects on hepatic and renal complications in type 2 diabetic rats, suggesting potential as new therapies.

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Cite This Study

Meenu et al. (2026) studied this question.

synapsesocial.com/papers/6a61afaefaa9903c5116a766 https://doi.org/10.1177/0976500x261463364

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Hesperetin and Isoliquiritigenin Ameliorates the Hepatic and Renal Complications in Type 2 Diabetic Rats

Key Points

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Implication

Discussion

Cite This Study

Hesperetin and Isoliquiritigenin Ameliorates the Hepatic and Renal Complications in Type 2 Diabetic Rats

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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