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July 23, 2026European Journal of Clinical NutritionOpen Access

Adolescent mothers’ body composition and metabolic hormones (adiponectin, ghrelin, and leptin) in blood and human milk: associations with infant body composition

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Authors

VRVerônica RachedERElaine Pereira de RezendeMDMaria Eduarda Leão Diógenes

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Overview

Randomized trial investigates maternal metabolic hormones' effects on infant body composition, indicating significant associations with growth measures.

Key Points

  • This study investigates the relationship between maternal body composition and metabolic hormones in blood and milk, and their associations with infant body composition.
  • Evaluated 55 adolescent mother-infant pairs at postpartum using dual-energy X-ray absorptiometry.
  • Measured leptin, adiponectin, and ghrelin in maternal blood and human milk.
  • Used multiple linear regression models to assess associations adjusted for days postpartum and birth weight.
  • Serum and human milk leptin showed a direct association (r = 0.472; p = 0.014).
  • Greater maternal fat mass was linked to higher leptin concentrations in both serum and milk (β = 5.95; 95% CI: 1.65–10.3).
  • Higher milk leptin associated with lower infant length (β = -1.21; 95% CI: −2.24, −0.183).

Cite This Study

Rached et al. (2026) studied this question.

synapsesocial.com/papers/6a61b02ffaa9903c5116ac2ahttps://doi.org/10.1038/s41430-026-01784-5
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