A case report demonstrates the use of 68Ga-FAPI PET/CT to identify synovitis in osteoarthritis, indicating a possible treatment target.
A 56-year-old patient was initially diagnosed with aseptic loosening of a left acetabular prosthesis based on 68Ga-FAPI. Half a year after revision, this patient developed right hip pain and a subsequent 68Ga-FAPI was performed revealing increased tracer uptake in the right hip, leading to a diagnosis of synovitis-induced osteoarthritis. This case highlights the utility of 68Ga-FAPI-PET/CT in visualizing synovial activity and underscores the potential role of synovitis in the pathogenesis of osteoarthritis.
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Wang et al. (2026) studied this question.
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