Key result
Dual antiplatelet therapy with ticagrelor and aspirin in patients undergoing intracranial stenting resulted in a 3.3% rate of thromboembolic complications and no new intracerebral hemorrhages.
Why the study?
Dual antiplatelet therapy with aspirin and clopidogrel prevents thromboembolic complications after neuroendovascular procedures, but clopidogrel resistance confers a higher risk of thromboembolism.
Does DAPT with ticagrelor and aspirin safely prevent thromboembolic complications in patients undergoing intracranial stenting procedures?
Cohort (n=151)
No
Does DAPT with ticagrelor and aspirin safely prevent thromboembolic complications in patients undergoing intracranial stenting procedures?
DAPT with ticagrelor and aspirin appears safe and effective for preventing thromboembolic complications without increasing hemorrhagic risk in patients undergoing intracranial stenting.
May support ticagrelor-aspirin DAPT for clopidogrel-resistant intracranial stenting; leaves open need for randomized confirmation.
BACKGROUND: Thromboembolic complications are one of the major periprocedural complications following neuroendovascular procedures. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel remain the principal agents for prevention of thromboembolic complications. However, clopidogrel resistance is associated with higher risk of thromboembolic complications. This study investigated the safety and efficacy of DAPT with ticagrelor and aspirin in patients undergoing intracranial stenting procedures. METHODS: This retrospective study was based on patients with intracranial aneurysms who undergoing intracranial stenting procedures at our institution between August 2017 and July 2020. These patients received DAPT with ticagrelor and aspirin were included. DAPT with 90 mg ticagrelor twice daily and aspirin 100 mg daily was continued for 3 months after the intracranial stenting procedure and aspirin continued for 1 year. RESULTS: In this study, 151 patients were identified. The most common aneurysm location was the internal carotid artery with 127 (71.8%) patients. Of the 151 cases with 160 treated aneurysms, 30 (18.8%) patients were treated by flow diverters (FDs), and 130 (81.2%) by stent-assisted coiling. Five (3.3%) patients had thromboembolic complications. Intraprocedural aneurysmal rupture was observed in one patient because of coil extrusion during coil insertion. None of the patients showed a newly DAPT-related intracerebral hemorrhage. Two patients developed dyspnea, and the symptom resolved without intervention. Furthermore, ecchymoma and gastrointestinal bleeding occurred in one patient respectively. DAPT-related thromboembolic and hemorrhagic complications were not significantly different between the FD group and stent-assisted coiling group. CONCLUSIONS: In our study, DAPT combining ticagrelor and aspirin seems to be a safe and efficient treatment for preventing thromboembolic complications in patients with intracranial aneurysms, without any increase in hemorrhagic complications. Ticagrelor may be an effective alternative for patients undergoing neurointervention.
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Ma et al. (2022) conducted a cohort in Intracranial aneurysms undergoing intracranial stenting procedures (n=151). Dual antiplatelet therapy (ticagrelor and aspirin) was evaluated on Thromboembolic complications. Dual antiplatelet therapy with ticagrelor and aspirin in patients undergoing intracranial stenting resulted in a 3.3% rate of thromboembolic complications and no new intracerebral hemorrhages.
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