Key result
Recent reappraisals of hypertension guidelines suggest abandoning the ranking of first-choice agents in favor of individualized combination therapies, particularly RAS blockers with calcium antagonists.
The review emphasizes a shift in hypertension management from rigid first-line drug rankings to individualized combination therapies, notably RAS blockers with calcium antagonists.
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Some hypertension guideline recommendations remain poorly evidence-supported; leaves open need for targeted RCTs before practice shifts.
Michel Burnier (2010) conducted a review in Hypertension. Combination antihypertensive therapy was evaluated. Recent reappraisals of hypertension guidelines suggest abandoning the ranking of first-choice agents in favor of individualized combination therapies, particularly RAS blockers with calcium antagonists.
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