Why the study?
Does a fixed-dose combination of amlodipine/benazepril reduce a composite of cardiovascular events in high-risk hypertensive individuals compared to a fixed-dose combination of benazepril/hydrochlorothiazide?
Does a fixed-dose combination of amlodipine/benazepril reduce a composite of cardiovascular events in high-risk hypertensive individuals compared to a fixed-dose combination of benazepril/hydrochlorothiazide?
The ACCOMPLISH trial is designed to be the first large randomized trial to directly compare cardiovascular outcomes between two fixed-dose combination antihypertensive therapies in high-risk patients.
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Positions ACCOMPLISH as first large RCT of fixed-dose combinations; leaves open which regimen optimizes outcomes in high-risk hypertension.
Kenneth Jamerson (2003) studied this question.
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